33.3% of patients had no significant fatigue, 25.4% had mild-to-moderate fatigue, and 41.3% had significant fatigue. The patients were classified into three groups: no fatigue (FSS 5). VolBrain, a fully automated, operator-independent tool was used to assess WM-LL and whole brain volume. Each patient provided demographic details and was scored on the expanded disability status scale (EDSS) and fatigue severity scale (FSS). ![]() 63 patients with RRMS participated in this study mean age was 31.9 ± 8.1 years. Here we assess the relation between fatigue and regional WM-LL volumetric measures. Many studies have linked grey matter atrophy to fatigue, but white matter lesion load (WM-LL) has received less attention. ![]() Fatigue is a common disabling symptom of relapsing remitting multiple sclerosis (RRMS).
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